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Updated: Aug 11, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
Published on: February 7, 2019
Diastereoselective synthesis of highly functionalized tetrahydroxanthenols--unprecedented access to privileged
Carl F Nising1, Ulrike K Ohnemüller, Anne Friedrich
1Institut für Organische Chemie, Universität Karlsruhe TH, Fritz-Haber-Weg 6, 76131 Karlsruhe, Germany.
Abstract:
Tetrahydroxanthenones, which can be easily prepared by a domino oxa-Michael aldol condensation, offer various possibilities for diastereoselective functionalization, giving access to the stereocontrolled synthesis of stereochemical triades or tetrades, which represent privileged structural motifs. In most cases, the relative stereochemistry was unequivocally established by crystal structure analysis.
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