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Related Experiment Videos

Alkaline encrusted pyelitis.

S Van Hooland1, A K Vandooren, E Lerut

  • 1Department of Nephrology, University Hospital Gasthuisberg, 3000 Leuven, Belgium. saimen@fil-saimen.be

Acta Clinica Belgica
|March 1, 2006
PubMed
Summary
This summary is machine-generated.

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Alkaline encrusted pyelitis, a rare infection causing kidney damage, is linked to Corynebacterium group D2. Early diagnosis and conservative treatment including antibiotics and urine acidification can prevent the need for dialysis.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Urology

Background:

  • Alkaline encrusted pyelitis is a severe upper urinary tract infection characterized by inflammation and encrustations.
  • It is strongly associated with Corynebacterium group D2, an urea-splitting bacterium.
  • Predisposing factors include prior urological procedures and immunosuppression, potentially leading to end-stage renal failure.

Observation:

  • Diagnosis relies on clinical suspicion, unenhanced computed tomography (CT) scans, and bacteriologic isolation of Corynebacterium group D2.
  • The condition can cause significant destruction of native kidneys and kidney grafts.

Findings:

  • Treatment involves a multi-faceted approach: antibiotic therapy (glycopeptides preferred), urine acidification, chemolysis, and potentially surgical intervention.

Related Experiment Videos

  • A case report highlights successful conservative management with antibiotics and combined oral/local acidification, avoiding dialysis.

    • Implications:

    • This case underscores the importance of prompt diagnosis and conservative management for alkaline encrusted pyelitis.
    • Effective treatment can potentially avert severe kidney damage and the need for renal replacement therapy such as dialysis.
    • Further research into optimal antibiotic strategies and acidification protocols may improve patient outcomes.