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Updated: Aug 11, 2026

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
08:41

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues

Published on: June 3, 2019

[The condition of vascular-thrombocyte hemostasis in the elderly with arterial hypertension]

V P Nosov, N N Borovkov, O G Bashiukova

    Klinicheskaia Meditsina
    |March 1, 2006
    PubMed

    Insights

    Elderly patients with arterial hypertension show increased vascular hemostasis and platelet aggregation. Systolo-diastolic arterial hypertension (SDAH) presents with more severe platelet issues than isolated systolic arterial hypertension (ISAH).

    Area of Science:

    • Cardiovascular Medicine
    • Hematology
    • Gerontology

    Context:

    • Arterial hypertension (AH) is prevalent in the elderly.
    • Understanding vascular and platelet function is crucial for managing AH in older adults.

    Purpose:

    • To analyze vascular-thrombocyte hemostasis parameters in elderly patients with systolo-diastolic arterial hypertension (SDAH) and isolated systolic arterial hypertension (ISAH).

    Summary:

    • Uncomplicated AH in the elderly involves activated vascular hemostasis and increased platelet aggregation, indicated by elevated Willebrand factor and altered aggregation patterns.
    • SDAH, unlike ISAH, shows a higher prevalence of nocturnal blood pressure surges and more significant thrombocyte hyperfunction.
    • These distinct hemostatic profiles suggest tailored disaggregation therapy approaches are needed for different AH types in the elderly.

    Impact:

    • Highlights specific hemostatic differences between SDAH and ISAH in elderly populations.
    • Informs clinical decisions regarding antiplatelet and disaggregation therapies for older hypertensive patients.
    • Contributes to personalized medicine strategies in geriatric cardiovascular care.

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