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Related Experiment Videos

Frontal horn cysts in normal neonates.

Chaw-Liang Chang1, Nan-Chang Chiu, Che-Sheng Ho

  • 1Department of Pediatrics, Mackay Memorial Hospital, 92, Section 2, Chung Shan North Road, Taipei, Taiwan, ROC.

Brain & Development
|March 1, 2006
PubMed
Summary

Frontal horn cysts (FHCs) in newborns are often benign and resolve spontaneously. This study found FHCs in 0.5% of healthy infants, with most resolving within months, suggesting a normal variant.

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Pediatrics and neonatology·2025

Area of Science:

  • Neonatal imaging
  • Pediatric neurology
  • Developmental pediatrics

Background:

  • Frontal horn cysts (FHCs) are thin-walled cysts near the lateral ventricles.
  • Their clinical significance and natural history in neonates require further elucidation.

Purpose of the Study:

  • To determine the incidence and sonographic characteristics of FHCs in healthy term infants.
  • To evaluate the natural history and resolution patterns of FHCs.

Main Methods:

  • Retrospective analysis of cranial ultrasound examinations in 3,545 term infants over 2 years and 5 months.
  • Documentation of FHC presence, laterality, and follow-up imaging for resolution.

Main Results:

  • FHCs were identified in 18 infants (0.5% incidence), mostly typical (17/18) and unilateral (11/18).

Related Experiment Videos

  • Resolution was observed in 12 infants within 11 months; 4 had normal development without documented resolution.
  • One infant with an atypical FHC showed transient enlargement but maintained normal development.

    • Conclusions:

    • FHCs in term infants may represent a normal physiologic variant or benign condition with high spontaneous resolution rates.
    • Typical FHCs can be monitored with serial ultrasounds at 1-2 and 6 months.
    • Atypical FHCs warrant closer follow-up and potentially advanced imaging (CT/MRI).