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[Effect of trimitazidine on insulin resistance in patients with coronary heart disease]
Jian-sheng Cai1, Zhi-jian Peng
1Department of Cardiology, Second People's Hospital of Shantoucity, Shantou 515011, China. caijiansen0829@sina.com.cn
Objective:
To evaluate the efficacy of trimetazidine on insulin resistance in patients with coronary heart disease (CHD).
Methods:
A cohort of 119 CHD patients were randomly divided into groups A and B receiving the same basic therapy, and the patients in group B were given additional trimetazidine 20 mg 3 times daily for 8 weeks. Before and after treatment, the changes in blood glucose, insulin levels and insulin sensitivity index were evaluated.
Results:
The patients in group B showed better outcome than those in group A. After 8 weeks' trimetazidine therapy, the fasting insulin and that at 2 h after oral glucose were decreased (P<0.01), and the insulin sensitivity index was improved (P<0.01).
Conclusion:
Trimetazidine may produce obvious therapeutic effect on insulin resistance in CHD patients.
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