Related Experiment Video

Updated: Aug 11, 2026

A Method for Screening and Validation of Resistant Mutations Against Kinase Inhibitors
12:40

A Method for Screening and Validation of Resistant Mutations Against Kinase Inhibitors

Published on: December 7, 2014

The effect of the JAK2 V617F mutation on PRV-1 expression

Zakar Mnjoyan, Donghoon Yoon, Jun Li

    Haematologica
    |March 1, 2006
    PubMed
    Summary

    The JAK2(V617F) mutation increases polycythemia rubra vera 1 (PRV-1) expression in myeloid cells. A JAK2 inhibitor reversed this effect, highlighting a potential therapeutic target for myeloproliferative disorders.

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