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Updated: Aug 11, 2026

Expression and Purification of Virus-like Particles for Vaccination
Published on: June 2, 2016
Fluarix, inactivated split-virus influenza vaccine
1Division of Infectious Diseases, The Ottawa Hospital, University of Ottawa, Ottawa, ON, K1H 8L6, Canada. grrose@ottawahospital.on.ca
Abstract:
Influenza is a potentially fatal respiratory infection resulting from several influenza virus strains. It causes annual epidemics of disease for which vaccination is the cornerstone of public health policy. The inadequacies of vaccine supply in the US during the 2004 influenza season revealed the deficiencies of current vaccine development and delivery. One outcome of this was the accelerated approval of an inactivated split-virus influenza vaccine, Fluarix. This paper reviews the immunogenicity and reactogenicity of this vaccine, and makes recommendations for the incorporation of Fluarix into the public health framework alongside other similar vaccines. Other directions to explore in an effort to secure future vaccine supply are considered.
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