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IL-4 alpha chain receptor (IL-4Ralpha) polymorphisms in allergic bronchopulmonary sspergillosis

Alan P Knutsen1, Barbara Kariuki, Judy D Consolino

  • 1Division of Allergy/Immunology, Saint Louis University Health Sciences Center and St, Louis, Missouri, USA. knutsenm@slu.edu

Clinical and Molecular Allergy : CMA
|March 1, 2006
PubMed
Abstract

Insights

Genetic variations in the IL-4 receptor alpha chain (IL-4Ralpha) are linked to allergic bronchopulmonary aspergillosis (ABPA). The ile75val IL-4Ralpha single nucleotide polymorphism (SNP) is a significant genetic risk factor for ABPA development.

Area of Science:

  • Immunogenetics
  • Respiratory Medicine
  • Molecular Biology

Background:

  • Allergic bronchopulmonary aspergillosis (ABPA) affects 7-10% of cystic fibrosis (CF) patients and 1-2% of asthmatics.
  • Genetic factors like HLA-DR restriction and IL-4 sensitivity are implicated in ABPA risk.

Purpose of the Study:

  • To investigate the presence of IL-4 receptor alpha chain (IL-4Ralpha) single nucleotide polymorphisms (SNPs) in ABPA patients.
  • To determine if these IL-4Ralpha SNPs correlate with increased sensitivity to IL-4 stimulation.

Main Methods:

  • Analysis of one extracellular (ile75val) and four cytoplasmic IL-4Ralpha SNPs.
  • Study included 40 ABPA CF patients, 22 ABPA asthmatic patients, and 56 non-ABPA controls.
  • IL-4 sensitivity assessed by measuring CD23 expression on B cells.

Main Results:

  • IL-4Ralpha SNPs were detected in 95% of ABPA patients.
  • The ile75val IL-4Ralpha SNP was the most prevalent, found in 80% of ABPA patients.
  • This SNP is an extracellular variant.

Conclusions:

  • The presence of IL-4Ralpha SNPs, particularly the ile75val variant, represents a genetic predisposition to ABPA.
  • These findings highlight the role of IL-4Ralpha genetics in ABPA pathogenesis.

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