Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Virus-mediated autoimmunity in Multiple Sclerosis.

Nikolaos Grigoriadis1, Georgios M Hadjigeorgiou

  • 1B' Department of Neurology, Laboratory of Experimental Neurology and Neuroimmunology, AHEPA University Hospital, 1 Stilp Kyriakidi Street, Aristotle University of Thessaloniki, Thessaloniki, 54636 Thessaloniki, Greece.

Journal of Autoimmune Diseases
|March 1, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Building Towards Initiation, Moderation, De-Escalation and Cessation of Disease-Modifying Treatments for Multiple Sclerosis in Greece: An Expert Panel Consensus Meeting.

Brain sciences·2026
Same author

A neurologist's guide to VEXAS syndrome: Differentiating somatic autoinflammation from autoimmune mimics.

Intractable & rare diseases research·2026
Same author

Sex-specific associations between reproductive history and late-life cognitive outcomes.

Journal of clinical and experimental neuropsychology·2026
Same author

Exploring the Personalisation of Digital Cognitive Rehabilitation in Multiple Sclerosis Through Wearable Data and Machine Learning.

Studies in health technology and informatics·2026
Same author

Prevalence of Essential Tremor among Greeks Aged 65 Years or Older: Results from the HELIAD Study.

Neuroepidemiology·2026
Same author

Development and expert refinement of a stratified framework for progression independent of relapse activity (PIRA) in multiple sclerosis.

Clinical neurology and neurosurgery·2026

Multiple Sclerosis (MS) may be an acquired autoimmune disease triggered by an environmental factor, possibly viral. While a specific virus remains unidentified, evidence suggests an autoimmune response underlies MS pathogenesis.

Area of Science:

  • Neuroimmunology
  • Infectious Disease Epidemiology

Background:

  • Multiple Sclerosis (MS) is increasingly viewed as an acquired autoimmune disease.
  • Genetic susceptibility combined with environmental factors, potentially infectious agents, is hypothesized as the cause.

Purpose of the Study:

  • To explore the potential role of infectious agents, particularly viruses, in triggering autoimmune responses in Multiple Sclerosis.
  • To reconcile the infectious and autoimmune hypotheses for MS etiology.

Main Methods:

  • Review of epidemiological data and clinical observations.
  • Analysis of evidence from viral-induced demyelinating encephalomyelitis models.
  • Consideration of cerebrospinal fluid findings, such as IgG oligoclonal bands.

Main Results:

Related Experiment Videos

  • Viral infections are suggested by cases of demyelinating encephalomyelitis and IgG bands in cerebrospinal fluid.
  • The lack of specific viral identification in the MS central nervous system presents a challenge to the viral hypothesis.
  • Partial response to immunosuppressive/immunomodulatory therapy supports an autoimmune basis for MS.

Conclusions:

  • While a definitive infectious agent is not identified, its transient presence cannot be excluded as a trigger for long-term autoimmune cascades in MS.
  • The interplay between initial infection and subsequent autoimmune mechanisms requires further investigation to fully understand MS pathogenesis.