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Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
Published on: May 10, 2024
Eosinophilic esophagitis -- a mimic of GERD
Richard Joseph Noel1, Neelesh Ajit Tipnis
1Division of Pediatric Gastroenterology and Nutrition, Medical College of Wisconsin, 9000 W. Wisconsin Ave., Milwaukee, WI 53226, USA. rnoel@mail.mcw.edu
International Journal of Pediatric Otorhinolaryngology
|March 1, 2006
Summary
Eosinophilic esophagitis (EE), a chronic condition mimicking GERD, is increasingly diagnosed. Diagnosis requires esophageal biopsy, and treatments include dietary changes and glucocorticoids.
Area of Science:
- Gastroenterology
- Immunology
- Pediatrics
Background:
- Eosinophilic esophagitis (EE) involves eosinophilic infiltration of the esophageal mucosa.
- EE symptoms can mimic gastroesophageal reflux disease (GERD).
- EE diagnosis is confirmed by esophageal biopsy showing elevated eosinophils.
Purpose of the Study:
- To review the current understanding of eosinophilic esophagitis.
- To highlight EE as an emerging mimic of GERD in clinical practice.
Main Methods:
- Review of current literature on EE.
- Analysis of diagnostic criteria and treatment efficacy.
Main Results:
- EE incidence has increased significantly in adults and children.
- Dietary and respiratory antigens are implicated in EE development.
- Glucocorticoids and dietary antigen elimination are effective treatments for EE.
Conclusions:
- EE is a chronic condition requiring increased awareness among clinicians managing reflux.
- Current evidence-based guidelines for EE management are lacking.
- Further research is needed to establish comprehensive management strategies.
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