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Immunostimulant properties of Heracleum maximum Bartr
Duncan Webster1, Pierre Taschereau, Timothy D G Lee
1Division of Infectious Diseases, University of Alberta, Edmonton, Alta., Canada T6G 2R7.
Journal of Ethnopharmacology
|March 1, 2006
Summary
Heracleum maximum root extracts show immunostimulant properties by increasing IL-6 production in macrophages. This scientific finding supports anecdotal evidence of its antiviral potential.
Area of Science:
- Immunology
- Pharmacology
- Ethnobotany
Background:
- Heracleum maximum root is traditionally recognized for antifungal and anti-mycobacterial effects.
- Anecdotal reports suggest potential antiviral properties, prompting investigation into its immunomodulatory capabilities.
Purpose of the Study:
- To investigate the immunostimulant properties of Heracleum maximum root extracts.
- To evaluate the capacity of these extracts to stimulate interleukin-6 (IL-6) production in macrophages.
Main Methods:
- Aqueous root extracts of Heracleum maximum were prepared.
- Macrophage activation assays were employed to measure IL-6 production.
- Experiments were conducted both with and without interferon-gamma (IFN-γ) stimulation.
Main Results:
- All tested Heracleum maximum extracts significantly stimulated IL-6 production in a dose-dependent manner.
- In the absence of IFN-γ, extracts increased IL-6 levels compared to controls.
- In the presence of IFN-γ, extracts markedly enhanced IL-6 production, exceeding that of the positive control (LPS + IFN-γ).
Conclusions:
- The study confirms the immunostimulant properties of Heracleum maximum root extracts.
- These findings provide a scientific basis for the traditional use and anecdotal reports of antiviral activity associated with this plant.
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