Related Experiment Videos
Alterations at the rel locus in human lymphoma
D Lu1, J D Thompson, G K Gorski
1Department of Neoplastic Diseases, Hahnemann University School of Medicine, Philadelphia, Pennsylvania 19102-1192.
Oncogene
|July 1, 1991
Summary
The rel proto-oncogene, implicated in non-Hodgkin's lymphoma, shows rearrangements in large cell lymphoma. Abnormal rel mRNA and gene alterations suggest its role in the disease's development.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- The rel proto-oncogene is located at chromosome region 2p11.2-14.
- This region is associated with nonrandom rearrangements in non-Hodgkin's lymphoma.
- The specific role of rel in lymphoma pathogenesis requires further investigation.
Purpose of the Study:
- To characterize the rel gene and its alterations in large cell lymphoma.
- To investigate the involvement of rel in the pathogenesis of diffuse and follicular large cell lymphoma.
Main Methods:
- Characterization of abnormal rel messenger RNA (mRNA) from a diffuse large cell lymphoma cell line.
- Analysis of rel gene rearrangement and amplification in lymphomatous tissues from patients with follicular and diffuse large cell lymphoma.
Main Results:
- An abnormal rel mRNA was identified, featuring a fusion of the N-terminal half of the rel coding region with an unrelated gene's C-terminal coding region.
- Rel gene rearrangement or amplification was detected in the lymphomatous tissue of three patients (two follicular, one diffuse large cell lymphoma).
Conclusions:
- The findings indicate that alterations in the rel proto-oncogene are associated with large cell lymphoma.
- The study suggests that rel plays a role in the pathogenesis of large cell lymphoma.