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Published on: June 15, 2011
Association between chromogranin A gene polymorphism and schizophrenia in the Japanese population
Nagahide Takahashi1, Ryoko Ishihara, Shinichi Saito
1Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Abstract:
It has been reported that expression of the chromogranin A (CHGA) gene is reduced in the prefrontal cortex and cerebrospinal fluid of patients with schizophrenia. Single-marker and haplotype analyses of SNPs within the CHGA gene were performed in 633 subjects with schizophrenia and 589 healthy controls. A significant association with schizophrenia was observed to one SNP marker, rs9658635 (p=0.0269), and with a 2 marker haplotype (p=0.0016). Significant association of rs9658635 was then replicated in a second independent cohort (377 schizophrenia and 338 control samples) (p=0.007). These results suggest that the CHGA gene is associated with the risk of developing schizophrenia in the Japanese population.
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