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Updated: Aug 11, 2026

Characterization of Leukocyte-platelet Rich Fibrin, A Novel Biomaterial
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Characterization of Leukocyte-platelet Rich Fibrin, A Novel Biomaterial

Published on: September 29, 2015

Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts and evolution

David M Dohan1, Joseph Choukroun, Antoine Diss

  • 1Biophysics Laboratory, Faculty of Dental Surgery, University of Paris V, Paris, France. drdohand@hotmail.com

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
|March 1, 2006
PubMed

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After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.