Related Experiment Video
Updated: Aug 11, 2026
Computed Tomography and Optical Imaging of Osteogenesis-angiogenesis Coupling to Assess Integration of Cranial Bone Autografts and Allografts
Published on: December 22, 2015
Bone regeneration after enucleation of mandibular cysts: comparing autogenous grafts from tissue-engineered bone and
Winnie Pradel1, Uwe Eckelt, Günter Lauer
1Department of Oral and Maxillofacial Surgery, University Hospital Carl Gustav Carus Dresden, Technical University Dresden, Germany. winnie.pradel@uniklinikum-dresden.de
Objective:
The aim of this study was to compare bone regeneration after grafting enucleated mandibular cyst cavities using either autogenous osteoblasts cultured on a biomaterial or autogenous spongiose iliac bone.
Study Design:
Twenty patients with 22 mandibular cysts were assessed. Eleven cysts were filled in with tissue-engineered bone (autogenous osteblasts cultured on demineralized bone matrix Osteovit) and 11 with spongiose iliac bone as controls. Panoramic radiographs were taken preoperatively, immediately postoperatively, and 3, 6, and 12 months after surgery. Radiolucency was computer analyzed using gray-level histograms.
Results:
In both groups bone regeneration took place in a similar fashion. After 3 and 6 months there were few differences in bone density between the groups. However, in radiographic controls after 12 months ossification was considerably stronger in cysts grafted with tissue-engineered bone.
Conclusion:
These results advocate for the clinical application of tissue-engineered bone as an alternative viable filling material for cysts.
