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Making the grade with models of persistent activity
Joshua T Dudman1, Steven A Siegelbaum
1Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA.
Abstract:
Persistent neural activity that outlasts an initial stimulus is thought to provide a mechanism for the transient storage of memory. In this issue of Neuron, Fransén et al. identify important principles for a cell-autonomous mechanism of graded persistent firing using an elegant combination of experimental and computational approaches.
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