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Related Experiment Videos

[A horse with Cushing's disease].

J H van der Kolk1, W R Klein, S W van der Putten

  • 1Vakgroep Inwendige Ziekten en Voeding der Grote Huisdieren, Faculteit Diergeneeskunde, Utrecht.

Tijdschrift Voor Diergeneeskunde
|July 1, 1991
PubMed
Summary

A pituitary pars intermedia adenoma caused sinusitis and adrenocortical insufficiency in a horse. This equine pituitary tumor led to hormonal imbalances and clinical signs, highlighting the importance of diagnostic evaluation.

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Area of Science:

  • Veterinary Medicine
  • Endocrinology
  • Equine Health

Context:

  • A 13-year-old Dutch Warmblood mare presented with chronic sinusitis.
  • Clinical signs included poor coat quality, pot-bellied appearance, and unilateral purulent nasal discharge.
  • Initial diagnostics revealed leucopenia and hyperglycemia.

Purpose:

  • To investigate the underlying cause of sinusitis and clinical signs in the mare.
  • To diagnose hormonal imbalances related to pituitary dysfunction.
  • To correlate necropsy findings with clinical presentation and diagnostic results.

Summary:

  • The mare exhibited clinical signs consistent with pituitary pars intermedia dysfunction.
  • Endocrine testing indicated adrenocortical insufficiency, with low basal cortisol and high basal ACTH.

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  • A dexamethasone suppression test showed incomplete suppression, further supporting pituitary pars intermedia dysfunction.
  • Necropsy confirmed a pituitary pars intermedia adenoma.

    • Impact:

    • This case highlights the potential for pituitary pars intermedia adenomas to cause diverse clinical signs in horses, including sinusitis.
    • Accurate diagnosis of equine pituitary pars intermedia dysfunction is crucial for appropriate management.
    • Understanding the endocrine consequences of pituitary tumors aids in veterinary diagnostics and treatment strategies.