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Updated: Aug 11, 2026

Measurement & Analysis of the Temporal Discrimination Threshold Applied to Cervical Dystonia
Published on: January 27, 2018
Familial dopa-responsive cervical dystonia
S A Schneider1, M D Mohire, I Trender-Gerhard
1Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, UCL, London, UK.
Abstract:
The authors present four cases from two unrelated families with young-onset predominant cervical dystonia with a dramatic sustained response to levodopa. Onset age was 12 years (range 9 to 15). Additional symptoms included postural hand tremor and laryngeal dystonia. Genetic testing for GTP cyclohydrolase I, tyrosine hydroxylase, and sepiapterin reductase was negative. These cases may represent new forms of dopa-responsive dystonia. Levodopa is advisable in all patients with young-onset cervical dystonia.
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