Related Experiment Videos
Paroxysmal nocturnal hemoglobinuria in childhood: an uncommon presentation
Vineeta Gupta1, V Tilak, S Vk Ramakrishna
1Department of Pediatrics, Pathology Institute of Medical Sciences, Banaras Hindu University, Varanasi - 221 005, India. sanjeevggupta@sancharnet.in
Abstract:
An eight year old boy presented with severe anemia and bleeding spots. Complete blood count showed pancytopenia. There was mild reticulocytosis. Bone marrow was hypocellular with normoblastic erythroid hyperplasia. Ham's test (acidified serum test) was positive which confirmed the diagnosis of Paroxysmal nocturnal hemoglobinuria (PNH). Although PNH is rare in childhood, it should be considered as a diagnostic possibility in cases of aplastic anemia as the two conditions can coexist. The presence of PNH in association with aplastic anemia can influence the outcome of the latter.
Related Concept Videos
Disorders of Erythrocytes
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
Bacterial Meningitis I: Introduction
Overview of Hematopoiesis
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
Rh Blood Group
Disorders of Hemostasis
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.