Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Central tolerance and autoimmune diseases].

Takeshi Nitta1, Yousuke Takahama

  • 1Division of Experimental Immunology, Institute for Genome Research, University of Tokushima.

Nihon Rinsho Men'Eki Gakkai Kaishi = Japanese Journal of Clinical Immunology
|March 1, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ZFP36L1 and ZFP36L2 cooperatively regulate thymic epithelial cell function to prevent early-onset thymic involution.

Cell death and differentiation·2026
Same author

Breaking the upper limit of mTEC heterogeneity.

Nature immunology·2026
Same author

Thymic cortical epithelial Psmb11-encoded β5t in mouse and human.

International immunology·2026
Same author

Epithelial chemokine CCL25 integrates T cell development and intestinal homeostasis.

The Journal of experimental medicine·2026
Same author

Proteasome alteration between epithelial and hematopoietic cells facilitates positive selection of CD8 T cells.

Nature communications·2026
Same author

Disrupting CD22-cis-ligand interactions ameliorates type 1 diabetes and graft rejection by expanding regulatory B cells.

PLoS biology·2026

Central tolerance prevents autoimmunity by selecting T lymphocytes in the thymus. Proper T-cell receptor (TCR) signaling and apoptosis are crucial for this process, while defects lead to autoimmune diseases.

Area of Science:

  • Immunology
  • Molecular Biology
  • Cell Biology

Context:

  • Central tolerance, established in the thymus, prevents autoimmune diseases by eliminating self-reactive T lymphocytes.
  • T-cell receptor (TCR) signaling strength dictates thymocyte survival or death during repertoire selection.
  • Dysregulation in TCR signaling (e.g., ZAP-70 mutations) or apoptosis (e.g., Bim deficiency) compromises central tolerance, leading to autoimmunity.

Purpose:

  • To elucidate the molecular mechanisms underlying central tolerance establishment in the thymus.
  • To investigate the role of T-cell receptor (TCR) signaling and apoptosis in thymic repertoire selection.
  • To understand the contribution of regulatory T cells and thymic medullary development to immune homeostasis.

Summary:

  • Central tolerance involves positive and negative selection of immature T lymphocytes in the thymus through differential ligand-TCR interactions and intracellular signaling.

Related Experiment Videos

  • Defects in TCR signaling (ZAP-70) or apoptosis (Bim) impair tolerance, causing autoimmunity.
  • Thymic repertoire selection also generates regulatory T cells and requires medullary development (NF-kappaB, AIRE) and thymocyte migration (CCR7).

    • Impact:

    • Understanding these mechanisms is crucial for developing therapies for autoimmune diseases.
    • Identifies key molecular players (ZAP-70, Bim, AIRE, NF-kappaB, CCR7) involved in immune self-tolerance.
    • Provides insights into the complex processes governing T cell development and the maintenance of immune homeostasis.