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Related Experiment Videos

Invasive candidiasis in the intensive care unit.

Luis Ostrosky-Zeichner1, Peter G Pappas

  • 1University of Texas Health Science Center at Houston, TX, USA.

Critical Care Medicine
|March 1, 2006
PubMed
Summary

Invasive candidiasis is increasingly common in intensive care units, with a rise in non-albicans Candida species. Management guidelines recommend specific antifungal agents, but research is needed for new therapies and diagnostics.

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Area of Science:

  • Infectious Diseases
  • Critical Care Medicine
  • Mycology

Background:

  • Invasive candidiasis presents significant morbidity and mortality, particularly in intensive care units (ICUs).
  • Epidemiologic trends indicate a rise in incidence and a shift towards non-albicans Candida species causing infections.

Purpose of the Study:

  • To review current epidemiologic trends of invasive candidiasis.
  • To discuss advances in diagnostic and susceptibility testing.
  • To outline therapeutic options, guidelines, and management strategies for ICU physicians.

Main Methods:

  • A non-structured review of peer-reviewed literature was conducted.
  • Sources included original articles, reviews, abstracts, guidelines, and consensus statements from major databases and proceedings.

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Main Results:

  • Invasive candidiasis is prevalent in ICUs, contributing to substantial patient morbidity and mortality.
  • A growing trend of infections and a shift to non-albicans Candida species have been observed.
  • Current guidelines suggest amphotericin B, fluconazole, or caspofungin as primary treatments, with agent choice dependent on local data and patient factors.

Conclusions:

  • Further research is essential in diagnostics, risk identification, and evaluating prophylactic, preemptive, and empirical management strategies.
  • The role of novel antifungal agents like new azoles and echinocandins requires further investigation for this patient population.