Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

[Outcome parameters in ankylosing spondylitis].

H Haibel¹, M Rudwaleit, J Sieper

¹hildrun.haibel@charite.de

Zeitschrift Fur Rheumatologie

|March 1, 2006

Summary

Ankylosing spondylitis outcome measures have advanced clinical trials. TNF-alpha blockers show high efficacy, while conventional disease-modifying antirheumatic drugs are ineffective for axial spondyloarthritis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Association between resolution of MRI-detected inflammation and improved clinical outcomes in axial spondyloarthritis under long-term anti-TNF therapy.

RMD open·2025

Same author

[History of the treatment of axial spondylarthritis with biologics-Part 1].

Zeitschrift fur Rheumatologie·2022

Same author

[Development of quality standards for patients with rheumatoid arthritis for use in Germany].

Zeitschrift fur Rheumatologie·2021

Same author

[Development of quality standards for patients with axial spondyloarthritis for use in Germany].

Zeitschrift fur Rheumatologie·2021

Same author

[Quality in acute inpatient rheumatology 2021 : Current aspects of the KOBRA quality label of the Association of Rheumatological Acute Care Clinics].

Zeitschrift fur Rheumatologie·2021

Same author

Mission statement from rheumatologists in the German Society of Rheumatology (DGRh e. V.) : We live rheumatology.

Zeitschrift fur Rheumatologie·2020

Area of Science:

Rheumatology
Clinical Trial Methodology
Inflammatory Diseases

Background:

Ankylosing spondylitis (AS) is a prevalent inflammatory rheumatic disease and a prototype of Spondyloarthropathies (SpA).
Numerous outcome parameters have been developed to assess various disease aspects and facilitate clinical trials.
Established indices include BASDAI, BASFI, BASMI, and quality of life questionnaires (SF-36, EQ-5D, ASQuol).

Purpose of the Study:

To review and highlight the development and application of outcome parameters in Ankylosing Spondylitis research.
To evaluate the efficacy of different treatment modalities in AS, particularly TNF-alpha inhibitors and conventional DMARDs.
To discuss radiological assessment tools for sacroiliac joints and spine in AS clinical trials.

Main Methods:

Review of established and emerging outcome parameters for AS assessment.
Analysis of clinical trial data utilizing these parameters to evaluate treatment efficacy.
Discussion of radiological scoring systems for sacroiliac joints (modified New York criteria, MRI scores) and spine (BASRI, mSASSS).

Main Results:

The development of new outcome parameters has enabled the demonstration of high efficacy for TNF-alpha blocking agents in AS.
The ASessments in AS (ASAS) criteria effectively measure short-term efficacy of NSAIDs and high efficacy of TNF-alpha blockers.
Conventional disease-modifying antirheumatic drugs (DMARDs) have shown ineffectiveness in treating axial forms of SpA.

Conclusions:

Modern outcome parameters are crucial for conducting robust clinical trials in AS.
TNF-alpha inhibitors represent a highly effective treatment for Ankylosing Spondylitis.
Conventional DMARDs are not effective for axial SpA, necessitating targeted therapies.

Related Experiment Videos