Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Base excision repair in nucleosome substrates.

Indu Jagannathan1, Hope A Cole, Jeffrey J Hayes

  • 1Department of Biochemistry and Biophysics, University of Rochester Medical Center, Box 712, NY 14642, USA.

Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology
|March 1, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Rahman Syndrome mutation in histone H1.4 disrupts chromatin compaction and phase separation.

Nature communications·2026
Same author

Conformations of Linker Histone H1 Bound to Nucleosome Arrays.

Journal of molecular biology·2026
Same author

Echinocandin Adaptation in <i>Candida albicans</i> Is Accompanied by Altered Chromatin Accessibility at Gene Promoters and by Cell Wall Remodeling.

Journal of fungi (Basel, Switzerland)·2025
Same author

Histone H3 Tail Modifications Alter Structure and Dynamics of the H1 C-Terminal Domain Within Nucleosomes.

Journal of molecular biology·2023
Same author

Histone H3 tail modifications regulate structure and dynamics of the H1 C-terminal domain within nucleosomes.

bioRxiv : the preprint server for biology·2023
Same author

Post-Translation Modifications and Mutations of Human Linker Histone Subtypes: Their Manifestation in Disease.

International journal of molecular sciences·2023

DNA repair enzymes must work within chromatin. This review explores how base excision repair (BER) enzymes interact with nucleosomes, suggesting compatibility and the influence of accessory factors.

Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • Eukaryotic DNA repair occurs within chromatin.
  • In vitro studies often use naked DNA, not reflecting cellular conditions.
  • Base excision repair (BER) is crucial for DNA lesion removal.

Purpose of the Study:

  • To review how BER enzymes function on nucleosomal DNA.
  • To explore the compatibility of BER with chromatin structure.
  • To examine the role of accessory factors and histone modifications in BER.

Main Methods:

  • Literature review of existing studies on BER and chromatin.
  • Analysis of in vitro and in vivo data on nucleosome-DNA interactions.
  • Examination of the impact of histone modifications and tails on BER factors.

Related Experiment Videos

Main Results:

  • Some BER enzyme activities are compatible with nucleosomal DNA.
  • Histone modifications and tail domains can modulate BER factor access and activity.
  • Accessory factors play a significant role in facilitating BER on nucleosomes.

Conclusions:

  • BER can occur efficiently within the chromatin context.
  • Understanding BER in chromatin is vital for comprehending genome stability.
  • Targeting chromatin-associated BER may offer therapeutic strategies.