Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Synaptic connection from cortical area V4 to V2 in macaque monkey.

John C Anderson1, Kevan A C Martin

  • 1Institute for Neuroinformatics, University of Zürich, and ETH Zürich, 8057 Zürich, Switzerland. jca@ini.phys.ethz.ch

The Journal of Comparative Neurology
|March 1, 2006
PubMed
Summary

The V4 projection in V2 primarily targets layer 1, forming excitatory synapses on dendritic spines and shafts, suggesting it excites pyramidal cells. This feedback projection shares similarities with feedforward projections but differs in terminal bouton location.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A strong direct link from the layer 3/4 border to layer 6 of cat primary visual cortex.

Brain structure & function·2024
Same author

Allometry: Alice in Pinwheel Land.

Current biology : CB·2021
Same author

Structure and function of a neocortical synapse.

Nature·2021
Same author

Translaminar circuits formed by the pyramidal cells in the superficial layers of cat visual cortex.

Brain structure & function·2017
Same author

A biological blueprint for the axons of superficial layer pyramidal cells in cat primary visual cortex.

Brain structure & function·2017
Same author

Synaptic connections formed by patchy projections of pyramidal cells in the superficial layers of cat visual cortex.

Brain structure & function·2017

Area of Science:

  • Neuroscience
  • Visual Cortex
  • Neuronal Projections

Background:

  • The V4 projection to V2 is characterized as a feedback pathway.
  • Understanding the precise targets and synaptic properties of this projection is crucial for deciphering visual information processing.

Purpose of the Study:

  • To investigate the laminar targets and synaptic characteristics of the V4 to V2 projection.
  • To compare the features of this feedback projection with known feedforward projections.

Main Methods:

  • Electron microscopy was used to analyze the V4 projection in V2.
  • Synaptic targets, including dendritic spines and shafts, were identified and quantified.
  • Synaptic morphology, size, and postsynaptic densities were examined.

Related Experiment Videos

Main Results:

  • The major target of the V4 projection in V2 is layer 1, forming asymmetric excitatory synapses.
  • Dendritic spines were the predominant targets (80-94%), with dendritic shafts also receiving input, particularly from smooth (GABAergic) cells.
  • Synapses in layer 6 were smaller than those in layer 1, and spine synapses had more complex postsynaptic densities than shaft synapses.

Conclusions:

  • The V4 to V2 feedback projection predominantly targets layer 1, exciting distal apical dendrites of pyramidal cells.
  • Despite similarities in synaptic targets and type, the laminar location of terminal boutons distinguishes feedback from feedforward projections.
  • The findings provide insights into the circuitry and function of the visual cortex.