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Viruses and cancer.

A G Dalgleish1

  • 1Retrovirus Research Group, MRC, Middlesex, UK.

British Medical Bulletin
|January 1, 1991
PubMed
Summary
This summary is machine-generated.

Viruses are now known to cause human cancers, dispelling previous beliefs. Research confirms links between viruses like HTLV, HIV, and HPV and cancer, offering new treatment and vaccination strategies.

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Area of Science:

  • Oncology
  • Virology
  • Epidemiology

Background:

  • Historically, viruses were known to cause animal cancers, but their role in human cancers was underestimated.
  • Recent discoveries include human retroviruses (HTLV, HIV) and established links for hepatitis B virus, Epstein Barr Virus, and human papilloma virus.

Purpose of the Study:

  • To document the association between specific viruses and human cancers.
  • To explore the molecular mechanisms by which viruses contribute to oncogenesis.
  • To identify potential new therapeutic and preventative strategies for virus-associated cancers.

Main Methods:

  • Large-scale epidemiological studies to establish correlations between viral infections and cancer incidence.
  • Molecular-level investigations to elucidate the mechanisms of viral oncogenesis.

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  • Review of existing literature on virus-associated cancers.

    • Main Results:

    • Confirmed association of human retroviruses (HTLV, HIV) with cancer development.
    • Documented malignant potential of hepatitis B virus, Epstein Barr Virus, and human papilloma virus.
    • Established viral oncogenesis as a significant factor in human cancer.

    Conclusions:

    • Viruses play a crucial role in a subset of human cancers.
    • Understanding viral oncogenesis provides insights into common cancer pathways.
    • Virus-associated cancers present opportunities for novel treatments and preventative vaccines.