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Quantitative perfusion imaging using arterial spin labeling.

Donald S Williams1

  • 1Imaging, Merck & Co Inc, West Point, PA, USA.

Methods in Molecular Medicine
|March 2, 2006
PubMed
Summary
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Arterial spin labeling (ASL) is a noninvasive MRI technique that uses endogenous water as a tracer for quantitative blood flow measurements. This method allows for repeated assessments, crucial for brain and renal perfusion imaging.

Area of Science:

  • Magnetic Resonance Imaging (MRI)
  • Physiology
  • Medical Imaging

Background:

  • MRI perfusion imaging utilizes exogenous contrast agents or endogenous tracers.
  • Arterial spin labeling (ASL) employs endogenous water as a freely diffusible tracer.
  • ASL perturbs blood water magnetization in arteries before it enters target tissues.

Purpose of the Study:

  • To focus on the technique of arterial spin labeling (ASL) for MRI-based perfusion imaging.
  • To describe the basic theory, experimental, and computational procedures for ASL.
  • To outline the extension of ASL for renal perfusion imaging.

Main Methods:

  • Utilizing endogenous water as a perfusion tracer.
  • Perturbing magnetization of blood water in arteries.

Related Experiment Videos

  • Employing continuous ASL (CASL) and pulsed ASL (PASL) variants.

    • Main Results:

    • ASL enables totally noninvasive, repeated quantitative blood flow measurements.
    • Absolute quantitation requires measurement of T1, transit time, and labeling efficiency.
    • Quantitative perfusion maps of the brain can be obtained using ASL.

    Conclusions:

    • ASL is a noninvasive MRI technique for quantitative blood flow assessment.
    • The technique allows for repeated measurements, limited by spin lattice relaxation time (T1).
    • ASL is applicable to brain perfusion imaging and can be extended to renal imaging.