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Published on: March 13, 2018
Design and characterization of magnetic resonance imaging gene reporters
1Department of Biomedical Engineering, University of California, Davis, USA.
Abstract:
We review the current status for magnetic resonance contrast agents that are designed to act as gene reporters. The basic concepts behind magnetic resonance and contrast enhancement are discussed, and factors that influence design of activatable contrast agents are presented. Several designs for magnetic resonance imaging (MRI) gene reporters are described, including contrast agents that are activated by beta-galactosidase, and marker genes that code for proteins that sequester iron. Methods to characterize the uptake and delivery of contrast agents are outlined.
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