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Ocular acyclovir delivery by collagen discs: a mouse model to screen anti-viral agents
D E Willey1, I Williams, C Faucett
1Department of Neurology, City of Hope National Medical Center, Duarte, CA 91010.
Current Eye Research
|January 1, 1991
Abstract:
Discs 1.6 mm in diameter trephined from corneal collagen shields were used to deliver acyclovir (ACV) to the cornea of mice inoculated with herpes simplex virus type 1 (HSV-1). In the first minute after application to the cornea, there was a 23% decrease of ACV in the discs. After the first minute, ACV clearance from the discs appeared to be exponential with a half-life of 21 minutes. Treatment given 3 times a day reduced HSV-1 titer in tear film, corneal tissue, and trigeminal ganglia. This animal model should be useful to conserve novel potential anti-viral drugs undergoing initial screening.