Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gastroretentive drug delivery systems.

Alexander Streubel1, Juergen Siepmann, Roland Bodmeier

  • 1College of Pharmacy, Freie Universität Berlin, Kelchstr. 31, 12169 Berlin, Germany. alexander.streubel@roche.com

Expert Opinion on Drug Delivery
|March 2, 2006
PubMed
Summary

Designing prolonged gastric residence time drug delivery systems is crucial for stomach-active drugs or those with upper GI absorption. This review covers factors influencing gastric emptying and strategies like bioadhesion, size-increase, and floating systems for enhanced drug delivery.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Editorial.

International journal of pharmaceutics: X·2026
Same author

Effect of drug solubility, polymer, and filler on drug release from modified-release matrix tablets in hydroethanolic media.

International journal of pharmaceutics·2026
Same author

Sonication-assisted emulsification: Analyzing different polymers in aqueous systems for microparticle preparation by the double emulsion technique.

Ultrasonics sonochemistry·2025
Same author

Perilymph sampling in Mongolian gerbil, technical note and procedure evaluation.

Hearing research·2025
Same author

Release of liposomes from hyaluronic acid-based hybrid systems: effects of liposome surface and size.

International journal of pharmaceutics·2024
Same author

Control of encapsulation efficiency and morphology of poly(lactide-co-glycolide) microparticles with a diafiltration-driven solvent extraction process.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V·2024

Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery
  • Gastroenterology

Background:

  • Controlled drug delivery systems with prolonged gastric residence time are vital for specific drug types.
  • These include drugs active in the stomach, those absorbed in the upper GI tract, or those unstable in the intestines.
  • Drugs with low solubility at high pH also benefit from extended stomach residence.

Purpose of the Study:

  • To provide an overview of factors influencing gastric emptying in humans.
  • To present key concepts in designing pharmaceutical dosage forms for prolonged gastric residence time.
  • To review different types of drug delivery systems and their clinical relevance.

Main Methods:

  • Review of parameters affecting human gastric emptying.

Related Experiment Videos

  • Discussion of design concepts for prolonged gastric residence time dosage forms.
  • Presentation and analysis of bioadhesive, size-increasing, and floating drug delivery systems.

    • Main Results:

    • Various factors influence gastric emptying, impacting drug absorption and efficacy.
    • Bioadhesive, size-increasing, and floating systems offer distinct mechanisms to prolong stomach residence.
    • Both single-unit and multiple-unit dosage forms are evaluated, with in vivo data where available.

    Conclusions:

    • Optimizing gastric residence time is a key strategy for improving the therapeutic efficacy of certain drugs.
    • Different drug delivery system designs present unique advantages and limitations that must be considered.
    • Further in vivo studies are valuable for validating the performance of these advanced drug delivery systems.