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VEGF-targeted therapy in renal cell carcinoma: active drugs and active choices

Brian I Rini1

  • 1Cleveland Clinic Foundation, 9500 Euclid Avenue/Desk R35, Cleveland, OH 44195, USA. rinib2@ccf.org

Current Oncology Reports
|March 2, 2006
PubMed

Insights

Targeting vascular endothelial growth factor (VEGF) pathways shows clinical activity in metastatic renal cell carcinoma (RCC). This article reviews VEGF-targeted agents, their biology, clinical results, and future use in RCC treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Nephrology

Background:

  • Renal cell carcinoma (RCC) involves molecular pathways like von Hippel-Lindau (VHL) gene inactivation.
  • VHL gene inactivation leads to increased vascular endothelial growth factor (VEGF) expression, promoting tumor growth.
  • VEGF and related pathways are key targets in metastatic RCC treatment.

Purpose of the Study:

  • To review the biology of VEGF-targeted agents in renal cell carcinoma.
  • To summarize clinical results of VEGF-targeted therapies in metastatic RCC.
  • To discuss future considerations for the optimal use of these agents.

Main Methods:

  • Literature review of studies on VEGF-targeted agents in RCC.
  • Analysis of clinical trial data for efficacy and safety.
  • Discussion of biological mechanisms and clinical outcomes.

Main Results:

  • VEGF-targeted agents have demonstrated substantial clinical activity in metastatic RCC.
  • Multiple agents targeting VEGF pathways are available for RCC treatment.
  • Significant clinical questions remain regarding the optimal application of these therapies.

Conclusions:

  • VEGF-targeted therapy is a crucial approach for managing metastatic RCC.
  • Further research is needed to optimize treatment strategies and address clinical questions.
  • Understanding the biology and clinical data is essential for advancing RCC care.

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