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Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Cardiac resynchronisation for patients with heart failure due to left ventricular systolic dysfunction -- a

N Freemantle1, P Tharmanathan, M J Calvert

  • 1Clinical Epidemiology and Biostatistics, Department of Primary Care and General Practice, Primary Care Clinical Sciences Building, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK. N.Freemantle@bham.ac.uk

European Journal of Heart Failure
|March 2, 2006
PubMed

Insights

Cardiac resynchronisation therapy (CRT) significantly lowers mortality and hospitalizations for heart failure patients with dyssynchrony. This therapy also enhances quality of life, demonstrating its effectiveness in managing advanced heart conditions.

Area of Science:

  • Cardiology
  • Medical Devices
  • Clinical Trials

Background:

  • Randomized controlled trials indicate cardiac resynchronisation therapy (CRT) benefits heart failure patients with left ventricular systolic dysfunction and cardiac dyssynchrony.
  • A comprehensive synthesis of CRT's impact on mortality, morbidity, quality of life, and implantation success is needed.

Purpose of the Study:

  • To systematically evaluate the effects of cardiac resynchronisation therapy (CRT) on mortality, major morbidity, quality of life, and implantation success rates.
  • To provide a valid synthesis of evidence from randomized trials on CRT in heart failure management.

Main Methods:

  • Systematic overview and meta-analysis of blinded and open-label randomized trials comparing CRT with control.
  • Primary outcome: all-cause mortality. Secondary outcomes: heart failure hospitalizations, quality of life (Minnesota Living with Heart Failure Questionnaire), and implantation success rates.

Main Results:

  • Eight randomized trials with 3380 patients were analyzed, with follow-up up to 29.4 months.
  • CRT significantly reduced all-cause mortality (OR 0.72, 95% CI 0.59-0.88) and hospitalizations for worsening heart failure (OR 0.55, 95% CI 0.44-0.68).
  • Quality of life improved (WMD -7.1, 95% CI -2.9 to -11.4), and implantation success rates were ≥87%.

Conclusions:

  • Cardiac resynchronisation therapy in heart failure patients with dyssynchrony substantially reduces all-cause mortality.
  • CRT significantly decreases major morbidity and improves quality of life in eligible heart failure patients.
Abstract

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