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Updated: Aug 11, 2026
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A Neonatal Heterotopic Rat Heart Transplantation Model for the Study of Endothelial-to-Mesenchymal Transition
Published on: July 21, 2023
Neonatal heart transplantation to a physiologic single lung
Tajinder P Singh1, Julio C Vasquez, Ralph Delius
1Division of Cardiology, Department of Pediatrics, Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit, Michigan, USA. tp.singh@cardio.chboston.org
Summary
Single-lung heart transplantation shows promise in neonates with congenital heart disease. This case study details the successful clinical and hemodynamic course in an infant with hypoplastic left heart syndrome.
Area of Science:
- Cardiology
- Pediatric Surgery
- Transplantation Immunology
Background:
- Congenital heart disease (CHD) poses significant challenges in neonates.
- Heart transplantation is a viable option for complex CHD.
- Single-lung transplantation in CHD is established in older patients but not well-documented in neonates.
Observation:
- A neonate diagnosed with hypoplastic left heart syndrome (HLHS) presented for primary treatment.
- The infant underwent heart transplantation utilizing a single functioning right lung.
- Clinical and hemodynamic parameters were closely monitored post-transplant.
Findings:
- The neonate demonstrated a positive clinical and hemodynamic course following the single-lung heart transplant.
- This approach proved feasible in a neonatal patient with HLHS.
- The transplanted single lung effectively supported the patient's physiology.
Implications:
- This case suggests the potential feasibility of single-lung heart transplantation in neonates with specific CHDs.
- Further research is warranted to explore this strategy in a larger cohort.
- This approach may offer a novel therapeutic option for critically ill neonates with HLHS.
