Related Experiment Video
Updated: Aug 11, 2026

Measurement of Heart Contractility in Isolated Adult Human Primary Cardiomyocytes
Published on: August 9, 2022
A search to predict potential for drug-induced cardiovascular toxicity
1Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210, USA. hamlin.1@osu.edu
Abstract:
This is a brief review of properties of cardiovascular function that should be considered for interrogation in studies of toxicology and/or safety pharmacology for non-cardiologists and non-physiologists. Since concern over the rarely occurring, unusual, and drug-induced tachycardia, Torsade de pointes, is a leading cause for cessation of development of potential drugs and for removal of drugs from the market, therefore, the toxic manifestation of drugs will be emphasized. The putative origin of torsade de pointes, and the origin of the electrocardiogram and electrocardiographic features of ventricular arrhythmias will be discussed.
Related Concept Videos
Drug Toxicity: Risk factors
Drug Toxicity: Overview
Drug Discovery: Overview
Drug toxicity: Drug–Drug Interaction
Pharmacovigilance
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
Drug toxicity: Idiosyncratic Reactions