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Updated: Aug 11, 2026
A Comprehensive Protocol for Manual Segmentation of the Medial Temporal Lobe Structures
Published on: July 2, 2014
Comparison of manual and automatic section positioning of brain MR images
Thomas Benner1, Jonathan J Wisco, André J W van der Kouwe
1Department of Radiology and General Clinical Research Center, Massachusetts General Hospital, Athinoula A. Martinos Center, Harvard Medical School, 149 13th St, Rm 2301, Charlestown, MA 02129, USA. thomas.benner@nmr.mgh.harvard.edu
Abstract:
The study protocol was approved by the institutional review board and was in full compliance with HIPAA guidelines. Informed consent was obtained from all patients. The purpose of this study was to prospectively compare intra- and intersubject variability of manual versus automatic magnetic resonance (MR) imaging section prescription. In two examinations, T2-weighted series were acquired with both methods. All intrasubject and three of six intersubject section prescription variances were significantly higher for manual prescription (P < .01). Root mean square errors confirmed better coregistration of the automated approach (P < .001). Automatic section prescription leads to improved reproducibility of imaging orientations for intra- and intersubject series in clinical practice.
