Related Experiment Video
Updated: Aug 11, 2026
Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats
Published on: October 16, 2010
Anticancer effect of Kalpaamruthaa on mammary carcinoma in rats with reference to glycoprotein components, lysosomal
Krishnamurthy Veena1, Palanivelu Shanthi, Panchanatham Sachdanandam
1Department of Medical Biochemistry, Dr. A. L. Mudaliar Post-Graduate Institute of Basic Medical Sciences, University of Madras, Chennai, India.
Abstract:
A promising approach to reduce the occurrence of cancer is its treatment, specifically by chemical intervention through minor dietary constituents. Epidemiological studies suggest that specific pharmacologically active agents present in the diet might reduce cancer. A remarkable surge of interest in chemoprevention research has, thus, lead to the identification of many phytochemicals of dietary origin as effective potential chemotherapeutic agents. In the present investigation, attempt has been made to study the potency of Kalpaamruthaa (KA), a herbal preparation, against cancer. The changes in level of glycoprotein components, marker enzymes and lysosomal enzymes were carried out in 7,12-dimethylbenz(a)anthracene (DMBA) induced Sprague-Dawley rats. The changes in the body weights and volume were also determined. KA was administered at the dosage level of 100, 200, 300, 400 and 500 mg/kg body weight (BW) in olive oil orally for 14 d, after the induction period is completed (90 d). On administration of KA, the levels of the above enzymes and the changes in the body weights and volume were significantly normalized in a dose dependent manner. The present study shows that KA is effective at the dosage level of 300 mg/kg body weight in mammary carcinoma bearing rats.
Insights
Kalpaamruthaa (KA), a herbal preparation, shows potential in cancer treatment by normalizing glycoprotein and enzyme levels in rats. The study identified 300 mg/kg body weight as an effective dosage for mammary carcinoma.
Area of Science:
- Oncology
- Pharmacology
- Biochemistry
Background:
- Dietary constituents and phytochemicals are explored for cancer chemoprevention.
- Herbal preparations are investigated for their therapeutic potential against cancer.
Purpose of the Study:
- To evaluate the anti-cancer efficacy of Kalpaamruthaa (KA), a herbal preparation.
- To assess the impact of KA on glycoprotein components, marker enzymes, and lysosomal enzymes in a cancer model.
Main Methods:
- Induced mammary carcinoma in Sprague-Dawley rats using 7,12-dimethylbenz(a)anthracene (DMBA).
- Administered varying doses of KA (100-500 mg/kg BW) orally for 14 days post-induction.
- Monitored changes in body weight, volume, glycoprotein levels, and enzyme activities.
Main Results:
- KA administration normalized enzyme levels and body weight/volume changes in a dose-dependent manner.
- Significant normalization was observed at a dosage of 300 mg/kg body weight.
- KA demonstrated effectiveness in reducing markers associated with mammary carcinoma.
Conclusions:
- Kalpaamruthaa (KA) exhibits significant anti-cancer properties.
- The optimal effective dosage of KA for mammary carcinoma in this model is 300 mg/kg body weight.
- KA represents a promising chemotherapeutic agent derived from dietary sources.
