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Positive acute-phase inflammatory markers in different stages of chronic kidney disease

João Egidio Romão1, Adlei Rogério Haiashi, Rosilene Mota Elias

  • 1Nephrology Service, Hospital das Clínicas da FMUSP, São Paulo, Brazil. joao.egidio@uol.com.br

American Journal of Nephrology
|March 2, 2006
PubMed

Insights

Elevated acute-phase inflammatory markers like hsCRP are common in chronic kidney disease (CKD) and worsen with disease severity. Hemodialysis may help reduce this inflammation in predialysis patients.

Area of Science:

  • Nephrology
  • Immunology
  • Cardiovascular Medicine

Background:

  • Elevated acute-phase inflammatory markers are linked to increased cardiovascular disease risk.
  • This study investigates the association between inflammatory markers and chronic kidney disease (CKD) stages.

Purpose of the Study:

  • To determine the relationship between serum levels of high-sensitivity C-reactive protein (hsCRP) and alpha1-acid glycoprotein (alpha1-AGP) and renal function in CKD patients.
  • To compare inflammatory marker levels between CKD patients and hemodialysis patients.

Main Methods:

  • Evaluated 224 adult CKD patients stratified by glomerular filtration rate (GFR) and 94 hemodialysis patients.
  • Measured serum levels of hsCRP and alpha1-AGP.
  • Assessed renal function using GFR.

Main Results:

  • Mean hsCRP and alpha1-AGP levels were significantly higher in more severe stages of CKD.
  • A weak inverse relationship was observed between GFR and serum hsCRP and alpha1-AGP.
  • Hemodialysis patients showed reduced hsCRP levels compared to predialysis stage 5 CKD patients, suggesting a partial correction of inflammation.

Conclusions:

  • Approximately 50% of CKD patients, even early on, show an activated acute-phase response related to CKD stage.
  • Hemodialysis may partially ameliorate the inflammatory process seen in the predialysis phase of CKD.
Abstract

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