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Updated: Aug 11, 2026

Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging
11:27

Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging

Published on: December 4, 2016

[Non-ionic iodinated dimeric versus monomeric X-ray contrast media: effects on complement factors in vivo]

I Böhm1, U Speck, H Schild

  • 1Radiologische Universitätsklinik, Rheinische Friedrich-Wilhelms-Universität. ingrid.boehm@ukb.uni-bonn.de

Rofo : Fortschritte Auf Dem Gebiete Der Rontgenstrahlen Und Der Nuklearmedizin
|March 2, 2006
PubMed

Insights

Contrast media (CM) injections can alter complement factors, with dimeric iotrolan causing more reactions than monomeric iopromide. These effects were transient, typically resolving within 30 minutes post-injection.

Area of Science:

  • Radiology and Imaging
  • Immunology
  • Pharmacology

Background:

  • Contrast media (CM) are essential in medical imaging.
  • CM can elicit adverse reactions, including complement activation.
  • Understanding CM-induced immunological responses is crucial for patient safety.

Purpose of the Study:

  • To investigate contrast media (CM)-induced alterations of complement factors.
  • To compare the effects of iotrolan and iopromide on complement pathways.

Main Methods:

  • Serum samples from 31 patients receiving iotrolan or iopromide for CT scans were analyzed.
  • Complement factors (C1q, C3, C4, C5a, C1-esterase inhibitor) were measured pre- and post-CM injection at various time points.
  • Incidence of CM reactions was recorded.

Main Results:

  • 16.1% of patients experienced CM reactions, with 4/5 occurring in the iotrolan group.
  • CM administration showed a transient tendency for complement factor levels to decrease, returning to baseline within 30 minutes.
  • Iotrolan induced more pronounced, though not statistically significant, changes in C3 and C4 compared to iopromide, suggesting potential classical pathway activation.

Conclusions:

  • CM injection transiently affects complement factors, with most changes resolving within 30 minutes.
  • Dimeric iotrolan was associated with a higher frequency of adverse reactions compared to monomeric iopromide.
  • Further research with larger patient cohorts is needed to confirm if iotrolan activates the classical complement pathway.
Abstract

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