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Cardiovascular risk factors in hemodialysis and peritoneal dialysis patients

F M Yilmaz1, G Yilmaz, M Duranay

  • 1Clinical Biochemistry Laboratory, Ministry of Health, Ankara, Turkey.

Scandinavian Journal of Clinical and Laboratory Investigation
|March 3, 2006
PubMed

Insights

Cardiovascular disease (CVD) is a major risk for hemodialysis (HD) and peritoneal dialysis (CAPD) patients. This study found higher homocysteine (Hcy), high-sensitivity C-reactive protein (hs-CRP), and apolipoprotein(a) [Lp(a)] levels in HD and CAPD patients compared to controls.

Area of Science:

  • Nephrology
  • Cardiology
  • Clinical Chemistry

Background:

  • Cardiovascular disease (CVD) is a leading cause of mortality in patients undergoing hemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD).
  • Investigating cardiovascular risk factors is crucial for managing CVD in dialysis populations.

Purpose of the Study:

  • To compare cardiovascular risk factors between HD and CAPD patients.
  • To identify correlations between specific biomarkers and CVD in dialysis patients.

Main Methods:

  • Study included 30 HD patients, 30 CAPD patients, and 30 healthy controls.
  • Measured levels of apolipoprotein A-I (apo A-I), apolipoprotein B (apo B), apolipoprotein(a) [Lp(a)], high-sensitivity C-reactive protein (hs-CRP), homocysteine (Hcy), and lipid profiles.

Main Results:

  • HD and CAPD patients exhibited elevated Hcy, Lp(a), and hs-CRP levels compared to controls.
  • Apo A-I/apo B ratios were lower in both HD and CAPD groups versus controls.
  • No significant differences in measured biomarkers were observed between HD and CAPD groups.

Conclusions:

  • Dialysis patients (HD and CAPD) present with increased cardiovascular risk markers.
  • Hypertension, age, and hs-CRP levels are positively correlated with CVD in this population.
Abstract

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