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Updated: Aug 11, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
[Application of fluoroquinolons in practice of the intensive therapy departments]
Abstract:
The review on the most studied class of antimicrobal preparations - fluoroquinolons (FQ) - is presented. Peculiar attention is paid to FQ, which were registered in the Ukraine (ciprofloxacine, ofloxacine, gatifloxacine, moxifloxacine). The data concerning chemical structure, pharmacokinetics of FQ, obtained during last years, are presented. The advantages and faults of definite representatives of FQ class are depicted. Principles of clinical administration of FQ, basing on the departments passportization and determination of the microbic agents sensitivity, are adduced.
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