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Updated: Aug 11, 2026

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
Published on: May 10, 2024
[Eosinophil granule cationic proteins: eosinophil activation markers]
P Guilpain1, L Guillevin, L Mouthon
1Faculté de Médecine, Université Paris-Descartes, UPRES-EA 1833, Paris, France.
Introduction:
Eosinophils play a central role in the pathogenesis of allergic diseases and host protection against parasites, especially against helminths.
Exegesis:
Eosinophil granules contain cytotoxic proteins, including cationic proteins: major basic protein (MBP), eosinophil cationic protein (ECP), eosinophil peroxidase (EPO) and eosinophil derived neurotoxin (EDN).
Conclusion:
Eosinophil granule proteins are implicated in the occurrence of allergic diseases and Churg-Strauss syndrome. These proteins are activation markers of eosinophils and may be useful in clinical practice.

