Helicobacter pylori as a prognostic indicator after curative resection of gastric carcinoma: a prospective study
View abstract on PubMed
Summary
This summary is machine-generated.Helicobacter pylori (H pylori) infection status significantly impacts survival after gastric cancer surgery. Patients negative for H pylori showed poorer relapse-free and overall survival rates compared to those positive for the infection.
Area Of Science
- Oncology
- Gastroenterology
- Infectious Disease
Background
- The prognostic significance of Helicobacter pylori (H pylori) status following curative resection for gastric adenocarcinoma remains unclear.
- Investigating H pylori's impact on patient outcomes is crucial for refining treatment strategies.
Purpose Of The Study
- To evaluate the association between H pylori infection status and survival outcomes in patients undergoing curative resection for gastric adenocarcinoma.
- To identify H pylori as a potential prognostic factor in gastric cancer.
Main Methods
- Prospective follow-up of 166 patients with R0 resection for gastric adenocarcinoma between 1992 and 2002.
- H pylori status determined pre-operatively using bacterial culture, histology, and serology.
- Assessment of relapse-free survival (RFS) and overall survival (OS) in relation to H pylori status.
Main Results
- Patients positive for H pylori demonstrated significantly better RFS (56.7 months) and OS (61.9 months) compared to H pylori-negative patients (RFS 19.2 months, OS 19.2 months).
- H pylori infection was identified as an independent prognostic factor for both RFS (HR 2.16) and OS (HR 2.00).
- Tumor invasion depth, lymph node metastasis, and age ≥67.5 years were also independent prognostic factors for OS.
Conclusions
- H pylori-negative status is associated with a poorer prognosis in gastric adenocarcinoma patients post-curative resection.
- Downregulation of tumor-specific immune responses may contribute to the adverse outcomes in H pylori-negative individuals.
- Careful monitoring of H pylori-negative patients is recommended due to their unfavorable outlook.