Related Experiment Video
Updated: Aug 11, 2026

Real-Time Void Spot Assay
Published on: February 10, 2023
Successful alpha-1 receptor blockade therapy in a toddler with infrequent and difficult voiding
William Lane M Robson1, Alexander K C Leung
1Pediatric Urology, University of Oklahoma, USA.
Abstract:
A 3-year-old neurologically intact and behaviorally normal boy developed infrequent and difficult voiding subsequent to a soft tissue injury to the glans penis. Symptoms persisted for at least 9 months, and the course was complicated by diagnostic imaging evidence of a "markedly distended" bladder and a voiding diary that suggested elevated bladder volumes. Treatment with an alpha-1 receptor blocker normalized voiding within 24 hours. Discontinuation of the medication after 2 weeks resulted in recurrence of symptoms within 48 hours. Readministration of the medication resulted in prompt resolution of symptoms.
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