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Pubic hair of infancy: endocrinopathy or enigma?
Todd D Nebesio1, Erica A Eugster
1Department of Pediatrics, James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indiana, USA. tdnebesi@iupui.edu
Insights
Isolated pubic hair in infants is a rare, benign condition. This pubic hair typically resolves on its own by age 11 months, though long-term monitoring is advised.
Area of Science:
- Pediatric Endocrinology
- Dermatology
- Reproductive Health
Background:
- Pubic hair in infancy is uncommon and poorly understood.
- Early pubic hair development can indicate various endocrine conditions.
Purpose of the Study:
- To characterize the clinical presentation and natural history of isolated pubic hair in infants.
- To determine if isolated pubic hair of infancy is a benign condition or a variant of premature adrenarche.
Main Methods:
- Retrospective chart review of infants under 12 months with isolated pubic hair.
- Analysis of patient demographics, clinical findings, growth patterns, laboratory results, and bone-age radiographs.
Main Results:
- Eleven infants (6 male, 5 female) diagnosed with isolated pubic hair.
- Average age at diagnosis was 8.3 months; 73% had atypical hair location.
- Growth, labs, and bone age were normal; pubic hair resolved by 11 months in follow-up cases.
Conclusions:
- Isolated pubic hair of infancy appears to be a benign entity.
- Further research is needed to ascertain if it's an atypical variant of premature adrenarche and its long-term implications.
Abstract:
Pubic hair of infancy is a rare condition that has not been well-characterized. A retrospective chart review of infants <12 months of age who presented to our pediatric endocrine clinics with isolated pubic hair over the last 5 years was performed. Eleven patients were identified (6 male and 5 female). The average age at diagnosis was 8.3 +/- 2.0 months. The majority of patients (73%) had pubic hair in an atypical location. Growth pattern, laboratory evaluation, and bone-age radiographs were unremarkable for all the infants. Of the infants that returned for follow-up, pubic hair resolved by the age of 11.0 +/- 1.5 months. From our experience and review of the literature, we suggest that isolated pubic hair of infancy is a benign entity. However, long-term follow-up needs to be done to determine if pubic hair of infancy is an atypical variant of premature adrenarche, which may place these patients at risk for later adult disease.
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