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Immune status during odontogeneous abscesses and phlegmonas
I Dgebuadze1, G Menabde, B Korsantia
1Tbilisi State Medical Academy, Research Institute of Medical Biotechnology of Georgian Academy of Sciences, G. Eliava Institute of Bacteriophage, Microbiology and Virology, Tbilisi, Georgia.
Georgian Medical News
|March 3, 2006
Summary
Odontogeneous abscesses severely impair immune function, decreasing nonspecific, cell, and humoral immunity. Treatment should include immune modulators alongside standard therapies for these dental infections.
Area of Science:
- Immunology
- Stomatology
- Infectious Diseases
Background:
- Odontogeneous abscesses and phlegmonas represent critical challenges in stomatology.
- These conditions are associated with compromised host defense mechanisms.
Purpose of the Study:
- To investigate the immune status in patients with odontogeneous abscesses and phlegmonas.
- To evaluate changes in nonspecific, cell, humoral, and specific immunity.
Main Methods:
- Utilized modern immunologic research methods.
- Assessed parameters including phagocytosis, interferon levels, lymphocyte subsets (T-effectors, T-helpers, T-lymphocytes, T-suppressors, B-lymphocytes), immunoglobulins (Ig G, Ig M, Ig A), and specific antibodies.
- Conducted serologic studies for anti-staphylococcus antibodies and alpha-toxin presence.
Main Results:
- Demonstrated a significant reduction in nonspecific resistance, including complete phagocytosis, total phagocytosis count, and phagocytosis index.
- Observed decreased concentrations of alpha and beta interferon.
- Noted a decrease in T-lymphocyte subsets (T-effectors, T-helpers, T-lymphocytes, T-suppressors) and a slight decrease in B-lymphocytes, IgG, IgM, and IgA.
- Revealed a substantial increase in anti-staphylococcus antibodies and the presence of alpha-toxin, which is abnormal.
Conclusions:
- The study highlights a profound immune deficiency in patients with odontogeneous abscesses and phlegmonas.
- Results indicate the necessity of incorporating immunomodulatory therapy with etiological treatment for effective management.