Trisomy 2 and 20 in two hepatoblastomas

Cytogenetic analysis of two pediatric hepatoblastomas is presented, comparing results in primary tumor samples, nude mouse xenographs, and lung metastases in one case. Both tumors had trisomy 2 and 20 in the primary tumors, along with other structural abnormalities. In subsequent passages/metastases, both tumors showed structural changes in one chromosome 2, resulting in partial trisomy 2q, along with structural changes of other chromosomes. Partial trisomy 1q was also common to both tumors in late stages. Results are compared to those of embryonal rhabdomyosarcoma, where trisomy 2 has also been noted.