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Updated: Aug 11, 2026
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Published on: January 27, 2023
Investigation of treatment failure in neonatal echovirus 7 infection
Alison C Rentz1, Jane E Libbey, Robert S Fujinami
1Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT, USA. alison.rentz@childrens.harvard.edu
Abstract:
We describe a case of fatal neonatal enteroviral infection caused by echovirus 7. Multiple treatments, including specific antiviral therapy, were attempted and failed. Studies of the viral isolate, maternal plasma, intravenous immunoglobulin preparations and pleconaril were performed to identify potential causes for treatment failure.
Insights
Fatal neonatal enteroviral infection caused by echovirus 7 proved untreatable. Investigations into the viral isolate and treatments like pleconaril aimed to understand therapy failure in this severe neonatal case.
Area of Science:
- Neonatal Medicine
- Virology
- Infectious Diseases
Background:
- Neonatal enteroviral infections represent a significant cause of morbidity and mortality.
- Echovirus 7 is a known enterovirus serotype that can cause severe disease in neonates.
Observation:
- A case of fatal neonatal infection attributed to echovirus 7 is presented.
- Despite multiple therapeutic interventions, including specific antiviral agents, the infection was refractory to treatment.
Findings:
- Studies were conducted on the echovirus 7 isolate, maternal plasma, and intravenous immunoglobulin preparations.
- Analysis included the antiviral drug pleconaril to elucidate the reasons for treatment failure.
Implications:
- Understanding treatment failures in neonatal enteroviral infections is crucial for developing effective therapeutic strategies.
- This case highlights the challenges in managing severe viral infections in newborns and the need for further research into novel treatment approaches.
