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Exserohilum: an emerging human pathogen.

A Adler1, I Yaniv, Z Samra

  • 1Unit of Pediatric Infectious Diseases and Hospital Infection Control, Schneider Children's Medical Center of Israel, 14 Kaplan Street, POB 559, Petah Tiqva, 49202, Israel. amosa@hadassah.org.il

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
|March 3, 2006
PubMed
Summary
This summary is machine-generated.

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Exserohilum fungal infections can cause various human diseases. Early diagnosis and treatment, especially combining antifungal agents, improve outcomes, though underlying health conditions remain critical factors.

Area of Science:

  • Medical Mycology
  • Infectious Diseases

Background:

  • Exserohilum is a dematiaceous fungus implicated in human infections.
  • These infections range from superficial (skin, cornea) to invasive disease and allergic fungal sinusitis.

Observation:

  • This study details two new Exserohilum infection cases and reviews 33 literature cases.
  • Most cases occurred in hot climates; risk factors included impaired immunity, local trauma, and atopy.
  • Invasive infections often required Amphotericin B combined with triazoles for better response.

Findings:

  • Allergic fungal sinusitis was primarily treated with surgical debridement.
  • Outcomes for Exserohilum infections appear more favorable than other mold infections.
  • Patient prognosis is significantly influenced by the presence and management of underlying diseases.

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Implications:

  • Highlights the spectrum of Exserohilum-related diseases and their varied clinical presentations.
  • Emphasizes the importance of considering fungal etiologies in specific geographic and clinical contexts.
  • Suggests optimized therapeutic strategies involving combination antifungal therapy and addressing host factors for improved patient outcomes.