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The OCD collaborative genetics study: methods and sample description.

Jack F Samuels1, Mark A Riddle, Benjamin D Greenberg

  • 1Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287-7228, USA.

American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics
|March 3, 2006
PubMed
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This summary is machine-generated.

Genetic studies of obsessive-compulsive disorder (OCD) are underway. The OCD Collaborative Genetics Study (OCGS) collected data from families with OCD, providing a resource for identifying genetic links to the disorder.

Area of Science:

  • Psychiatry
  • Genetics
  • Clinical Psychology

Background:

  • Family and twin studies suggest a genetic component to obsessive-compulsive disorder (OCD).
  • Genetic factors underlying OCD have not yet been identified.
  • The OCD Collaborative Genetics Study (OCGS) was established to address this gap.

Purpose of the Study:

  • To describe the methods and clinical characteristics of participants in the OCGS.
  • To provide a valuable resource for future genetic studies of OCD.
  • To facilitate the identification of genes associated with OCD.

Main Methods:

  • A multi-site collaborative genetic linkage study involving 238 families.
  • Collection of blood specimens and blinded clinical data from 999 individuals, including 299 OCD-affected sibling pairs.

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  • Genome-wide linkage analysis was performed on affected relative pairs.

    • Main Results:

    • 624 individuals were diagnosed with definite OCD; 82 with probable OCD.
    • The mean age of affected individuals was 36 years, with 66% being female.
    • Mean age of onset for OCD symptoms was 9.5 years, with gender-specific comorbidities noted.

    Conclusions:

    • The OCGS provides a significant resource for genetic research into OCD.
    • Clinical data reveal distinct patterns of comorbidities in male and female OCD cases.
    • Further analysis of this cohort is expected to advance the understanding of OCD genetics.