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Physicochemical properties of signal receptor domains as the basis for sequence comparison
A L Berman1, A E Dityatev, D I Frishman
1Institute of Evolutionary Physiology and Biochemistry, Academy of Sciences, Leningrad, USSR.
Abstract:
1. An algorithm of sequence comparison based on average bulkiness of amino acids in protein domains and not requiring sequence alignment is described. 2. A complete evolutionary tree of the signal receptor proteins is built. The STE2 proteins are shown to belong to this family. 3. Factorial analysis of average bulkiness makes it possible to discriminate functional and intraspecies differences between proteins.