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Related Experiment Videos

Oral pigmentation induced by Premarin.

R Pérusse1, R Morency

  • 1Laval University, School of Dentistry, Québec City, Canada.

Cutis
|July 1, 1991
PubMed
Summary
This summary is machine-generated.

This study identifies a rare cause of oral pigmentation: Premarin use. This melanic pigmentation is an important consideration in diagnosing oral lesions.

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Area of Science:

  • Oral Medicine
  • Dermatology
  • Endocrinology

Background:

  • Pigmented lesions of the oral cavity present a broad differential diagnosis.
  • Differential diagnoses include systemic conditions (Addison's disease, Peutz-Jeghers syndrome) and local lesions (melanoma, Kaposi's sarcoma, amalgam tattoo, gingival melanosis).

Observation:

  • A rare case of oral pigmentation is presented.

Findings:

  • The observed oral pigmentation was of a melanic type.
  • This pigmentation was found to be related to the use of Premarin (conjugated estrogens).

Implications:

  • Clinicians should consider Premarin use in the differential diagnosis of oral melanic pigmentation.
  • This finding expands the known iatrogenic causes of oral mucosal pigmentation.